Somatic mutations in chromatin remodeler genes could modify the epigenomic landscape of CLL, but These are uncommon in this malignancy compared to other lymphoid neoplasms. CHD2 is mutated in 5% of CLL and seven% of MBL.75 The histone methyltransferase SETD2 and ARID1A are also mutated in a small proportion of people. Of Notice, MYD88 mutations and